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Literature summary extracted from
- Copper binding triggers compaction in N-terminal tail of human copper pump ATP7B (2016), Biochem. Biophys. Res. Commun., 470, 663-669 .
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 7.2.2.8 | copper | the four most N-terminal metal-binding domains in ATP7B, upon stoichiometric copper addition, adopt a more compact arrangement with higher thermal stability than in the absence of copper. No stable complex was found in solution between the metal-binding domains and the nucleotide-binding domain of ATP7B | Homo sapiens |  |
| 7.2.2.8 | Na+ | presence of 350 mM NaCl increases the thermal stability | Homo sapiens | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 7.2.2.8 | Homo sapiens | P35670 | - |
- |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 7.2.2.8 | ATP7B | - |
Homo sapiens |
| 7.2.2.8 | copper-transporting ATPase 2 | - |
Homo sapiens |
Temperature Stability [°C]
| EC Number | Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 7.2.2.8 | 51 | - |
melting temperature, apo-enzyme | Homo sapiens |
| 7.2.2.8 | 59 | - |
melting temperature, presence of copper | Homo sapiens |
| 7.2.2.8 | 61 | - |
melting temperature, presence of 350 mM NaCl | Homo sapiens |
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Release 2023.1 (January 2023)
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